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RISPERDAL(R) CONSTA(R) (risperidone) is used for the treatment of schizophrenia. Copies of this Form 10-K, as well as subsequent filings, are available online at , or on request from Johnson & Johnson. Some side effects seen with these medications

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include the absence
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of a menstrual period; breasts producing milk; the development of breasts by males; and the inability to achieve an erection. Tardive Dyskinesia (TD) is a serious, sometimes permanent side effect reported with RISPERDAL(R) CONSTA(R) and similar medications. Archives of General Psychiatry, 2005 Jun; 62(6):617-27. Using Alkermes' proprietary Medisorb(R)
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drug-delivery technology, the RISPERDAL(R) CONSTA(R) formulation encapsulates risperidone in microspheres made of a biodegradable polymer, which are suspended in a water-based solution and injected into the muscle.

In 2003 and is registered in more than 80 countries worldwide. RISPERDAL(R) CONSTA(R) was initially approved for the treatment of schizophrenia in the U.S. There is no known treatment for TD,

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but it may go away partially or completely if therapy is stopped. Bipolar disorder is a brain disorder that causes unusual shifts in a person's mood, energy and ability to function.
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Ortho-McNeil-Janssen Pharmaceuticals, Inc. The risk of developing TD and the brantley that it will become permanent is thought to increase with the length of therapy and the overall dose taken by the patient. The connection between prolactin levels and side effects is unknown.

Dedicated solely to mental health. This condition

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can develop after a brief period of therapy at low doses, although this is much less common. Caution should be exercised when RISPERDAL(R) CONSTA(R) is administered to a nursing woman.

J&JPRD is currently evaluating the FDA's complete response letter and will work with the Agency to resolve any outstanding questions.

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The company currently markets prescription medications for the treatment of schizophrenia, bipolar mania, and irritability associated with autistic disorder. Please inform your healthcare professional of any medications or supplements that you are taking. The polymer from which the microspheres are made
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breaks down into two naturally occurring compounds that are then eliminated by the body.

Janssen, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc., based in Titusville, N.J., is the only pharmaceutical company in the U.S. If signs of high blood sugar or diabetes develop, such as being thirsty all the time, going to the bathroom a lot, or feeling weak

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or hungry, contact your doctor. Extrapyramidal Symptoms (EPS) are usually persistent movement disorders or muscle disturbances, such as restlessness, tremors, and muscle stiffness. By standing up or sitting up slowly and following your healthcare professional's dosing instructions, this side effect can be reduced or it may go away over time. Is a member of the Johnson & Johnson family of companies.
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Complications of diabetes can be serious and even life threatening. FDA Issues Complete Response Letter for RISPERDAL(R) CONSTA(R) for the Adjunctive Maintenance Treatment of Bipolar
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Disorder TITUSVILLE, N.J., / - / -- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

RISPERDAL(R) CONSTA(R) (risperidone) is not approved

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for the treatment of patients with dementia-related psychosis. Risks and uncertainties include general industry conditions and competition; economic conditions, such as interest rate and currency exchange rate fluctuations; technological advances and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approvals; domestic and foreign health care reforms and governmental
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laws and regulations; and trends toward health care cost containment. High blood sugar and diabetes have been reported with RISPERDAL(R) CONSTA(R) and similar medications.
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SOURCE Johnson & Johnson Pharmaceutical Research & Development, L.L.C. If you have any questions about RISPERDAL(R) CONSTA(R) or your therapy, talk with your doctor. J&JPRD does not undertake to update any forward-looking statements

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as a result of new information or future events or developments.) (1) Kessler RC, Chiu WT, Demler O, Walters EE. It is often characterized by debilitating mood swings from extreme highs (mania) to extreme lows (depression), and affects 5.7 million, or 2.6 percent, of the American adult population in any given year.(1) RISPERDAL(R) CONSTA(R) is marketed in the U.S. In a study of people taking RISPERDAL(R) CONSTA(R), the
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most com side effects in the treatment of schizophrenia were headache, tremors, dizziness, restlessness, tiredness, constipation, indigestion, sleepiness, weight gain, pain in the limbs, and dry mouth. Call your doctor immediately if the person being treated develops symptoms such as high fever; stiff muscles; shaking; confusion; sweating; changes in pulse, heart rate, or blood pressure; or muscle pain and weakness. RISPERDAL(R) CONSTA(R) and similar medications can raise the blood levels of a hormone known as prolactin,
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causing a condition known as hyperprolactinemia. topical antibiotics and birth control

RISPERDAL(R) CONSTA(R)

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may make you more sensitive to heat. Treatment should be stopped if the person being treated has NMS. IMPORTANT SAFETY INFORMATION FOR RISPERDAL(R) CONSTA(R) Elderly Patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. (This contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995. By Janssen(R), Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could vary materially from J&JPRD's expectations and projections. If the person being treated has diabetes or risk factors such as being overweight or a family history of diabetes, blood sugar testing should be performed at the beginning and throughout treatment with RISPERDAL(R) CONSTA(R).

A further list and description of these risks, uncertainties and other factors can be found in Exhibit 99 of Johnson &

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Johnson's Annual Report on Form 10-K for the fiscal year ended. Avoid alcohol while on RISPERDAL(R) CONSTA(R). Inform your healthcare professional if you become pregnant or intend to become pregnant during therapy with RISPERDAL(R) CONSTA(R). Some people taking RISPERDAL(R) CONSTA(R) may feel faint or lightheaded when they
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stand up or sit up too quickly. Neuroleptic Malignant Syndrome (NMS) is a rare and potentially fatal side effect reported with RISPERDAL(R) CONSTA(R) and similar medicines. (J&JPRD) announced today that the Food and Drug Administration (FDA) has asked for The Agency's complete response
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outlined questions that need to be addressed prior to granting approval for the new indication, but did not request additional studies.

Laboratory and clinical research has shown that the microspheres gradually degrade at a set rate to provide therapeutic blood levels of the drug in the bloodstream for an extended period. And manufactured by Alkermes, Inc. You may have trouble cooling off, or be more likely to become dehydrated, so take care when exercising or when doing things that make you warm. RISPERDAL(R) CONSTA(R) may affect your alertness or driving ability; therefore, do not drive or operate machinery before talking to your healthcare professional.

These statements are based on current expectations of future events. RISPERDAL(R) CONSTA(R) should be used cautiously in people with a seizure disorder, who have had seizures in the past, or who have conditions that increase their risk for seizures. Prevalence, severity, and comorbidity of twelve-month DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). If you observe any of these symptoms, talk to your healthcare professional. For more information about Janssen, visit.

Blood levels of prolactin remain elevated with continued use. Some medications interact with RISPERDAL(R) CONSTA(R). TD includes uncontrollable movements of the face, tongue, and other parts of the body.

   














Antibiotics are life-saving drugs that kill or inhibit bacterial growth by several different methods, including interference with cell wall, blocking of DNA synthesis, disruption of cellular processes, blocking of metabolism & nutrients.

Antivirals are drugs used to treat infections caused by viruses. Unlike antibiotics, which may cover a wide range of pathogens, antiviral agents tend to be narrow in their spectrum of action, and have limited efficacy. Antiviral agents include drugs that inhibit attachment, penetration and uncoating of certain viruses, as well as compounds that block the viral DNA replication process.


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