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Their current, two-pronged siRNA treatment avoids this problem -- at least

acyclovir
in mice. Like most anti-virals, this medicine will shorten the duration of the pain by up to 1 day, and can reduce the healing period required for your first (ever) outbreak of cold sores by 1 to 2 days. The preventive treatment uses small
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interfering RNA (siRNA)
acyclovir
molecules. It's considered a sexually transmitted infection, although mother-to-infant transmission occurs during the birth process. Is Docosanol 10% (aka "Abreva"), and it's the first and currently only non-prescription topical cream that has proved to shorten the duration of a cold sore outbreak.. Their study appears in the issue of Cell Host & Microbe.

Lieberman's team came up with an earlier version of

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their topical siRNA but found that the formulation they used actually encouraged herpes infection. So yes, if you've got or have ever had a cold sore, then you are permanently infected with the herpes virus,
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and as there are no actual known "cures" right now, you're never going to be rid of it. /hw-popup/oral-antiviral-medications-for-prevention-and-treatment-of-cold-sores
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) The two prescription-only creams available are Penciclovir and Acyclovir creams, which reduce the length of an outbreak by, possibly, 1 or 2 days. These tiny bits of genetic material are designed
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to switch off specific genes. Cold Sore Cures - Get Rid of Your Cold Sore Fast.

"One of the attractive features of the compound

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we developed is that it creates in the tissue a state that's resistant to infection, even if applied up to a week before sexual exposure," Harvard researcher Nancey Lieberman, PhD, says in a news release. If we can reproduce these results in people, this could have a powerful
genital herpes
impact on preventing transmission." HSV-2 is the main cause of genital herpes. But such "vaginal microbicides," even if effective, must be safe, non-messy, and long-lasting to be of real use to women. Lieberman and colleagues suggest their siRNA approach might also work against HIV. But if it works in sexually active adults, it would
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still be an enormous benefit to human health.

Cold sores, or oral herpes, are the most com form of the herpes simplex virus (HSV), with genital herpes being the second most common. It's also been shown that exposure to the

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strain normally responsible for cold sores, HSV-1, seems to reduce the symptoms of a later HSV-2 infection (i.e. "This aspect has a real practicality to it. Researchers have long believed that herpes and HIV could be prevented by vaginal application of antiviral agents. However, the same target they used in mouse vaginal cells -- a molecule called nectin-1 -- is also found on human vaginal cells. It may not harm humans, either, as the molecule seems to be needed during development but not during adult life. Potential side-effects include fever,
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itching, fatigue, headache, nausea,
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and diarrhea.

The other siRNA targets a viral bren required for herpes reproduction. This one is sometimes used to treat the type 1 strain of the virus that causes cold sores as well as the type 2 strain that causes genital herpes, and studies have proven that it will work

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just as well as Acyclovir for treating cold sores. An over-the-counter cream recently made available in the
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U.S. One keeps vaginal cells from producing a molecule that the herpes virus uses to infect cells. An estimated 536 million people worldwide are infected with HSV-2.

And HSV-2 infection makes it easier for a person to get infected with HIV. A funny thing about herpes

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simplex
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The odd thing is that contracting herpes causes an immune response called seroconversion from the body which releases antibodies to that specific strain of HSV which will thereby prevent an infection by that strain at any other site in the body--if you get oral herpes that means you are now immune to and cannot get herpes whitlow, herpes keratitis, or herpes encephalitis. Blocking nectin-1 doesn't seem to harm mice.
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Genital herpes),
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and most indications are that an HSV-2 infection will immunize that person against HSV-1, so if you get genital herpes odds are very good that you're now immune to and cannot get oral herpes (cold sores). (Source for oral anti-viral info. Over-the-counter creams such as Tetracaine
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cream (Viractin)
valacyclovir
and Lidocaine (Zilactin-L) are both supposed to reduce the pain and irritation of the cold sore only, they do not reduce the duration of the outbreak.

Valacyclovir was designed specifically to reduce the duration and severity of cold sores in people who are 12 years of age or older, and it's also been shown that Valacyclovir is absorbed much easier than other anti-viral medications such as Acyclovir. That suggests the drug might not be safe during pregnancy. The herpes treatment uses two siRNAs. Possible side effects include allergic reaction, headache, skin rash, insomnia, dizziness, and fatigue. This is because the virus remains dormant in the nerve cells near the initial site of infection, usually the face around the mouth and lips, until an active outbreak at which point it replicates enormous amounts of the virus, causing the sores, and then after the outbreak is over it retreats back into its dormant state.

The average cold sore outbreak lasts about a week for most people, although it can be as little as 2 and as many as 21 days in length (any longer than that and you should see a doctor immediately).

   
















Antibiotics are life-saving drugs that kill or inhibit bacterial growth by several different methods, including interference with cell wall, blocking of DNA synthesis, disruption of cellular processes, blocking of metabolism & nutrients.

Antivirals are drugs used to treat infections caused by viruses. Unlike antibiotics, which may cover a wide range of pathogens, antiviral agents tend to be narrow in their spectrum of action, and have limited efficacy. Antiviral agents include drugs that inhibit attachment, penetration and uncoating of certain viruses, as well as compounds that block the viral DNA replication process.


 
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